Coding

Part:BBa_K4645023

Designed by: Yuanpu Zhang   Group: iGEM23_HZAU-China   (2023-10-12)

MntA (MNT-domain protein)：An antitoxin

MntA is the antitoxin of the toxin protein HepT. Together they form a toxin-antitoxin system. The HepT/MntA system belongs to type VII TA, where the antitoxin neutralizes the toxicity of the toxin not through direct interaction, but by post-translational modification of the toxin's active site. MntA can bind to HepT and polyadenylate HepT, thereby neutralizing the toxicity of HepT and reducing its RNase activity [1].

Sequence and Features

Sequence and Features


Assembly Compatibility:
  • 10
    COMPATIBLE WITH RFC[10]
  • 12
    COMPATIBLE WITH RFC[12]
  • 21
    COMPATIBLE WITH RFC[21]
  • 23
    COMPATIBLE WITH RFC[23]
  • 25
    COMPATIBLE WITH RFC[25]
  • 1000
    COMPATIBLE WITH RFC[1000]

Reference

[1]Wang X, Yao J, Sun YC, Wood TK. Type VII Toxin/Antitoxin Classification System for Antitoxins that Enzymatically Neutralize Toxins. Trends Microbiol. 2021 May;29(5):388-393.

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